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KMID : 0931320170170030122
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대한상부위장관.헬리코박터학회지
2017 Volume.17 No. 3 p.122 ~ p.126
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Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma
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Jung Jin-Tae
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Abstract
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Approximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. pylori-negative gastric MALT lymphomas. H. pylori-negative gastric MALT lymphomas do not differ from H. pylori-positive gastric MALT lymphomas in terms of clinical features and endoscopic findings and show similar prognosis. H. pylori eradication therapy could be considered as first-line treatment for gastric MALT lymphomas regardless of their H. pylori infection status. In cases with H. pylori-negative gastric MALT lymphomas, the rate of response to eradication therapy varies from 0 to 83%. If gastric MALT lymphoma persists for more than a year, secondary treatment with radiotherapy, chemotherapy, and/or surgery should be considered. Of note, the comparative outcome is excellent.
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KEYWORD
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Helicobacter pylori, Lymphoma, B-cell, marginal zone
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